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The article says tesofensine blocks the reuptake of norepinephrine, dopamine, and serotonin in the brain, while tirzepatide activates GLP-1 and GIP receptors in the gut and brain

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Hasan GM, Anwar S, Shamsi A et al (2024) The neuroprotective potential of phytochemicals in traumatic brain injury: mechanistic insights and pharmacological implications

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In the clinical trials so far, blood sugar effects have been manageable (retatrutide actually improved blood sugar in diabetic patients), and muscle loss has been proportional to weight loss