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Vitamin B12 deficiency in over 16s: diagnosis and management.

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Commonly used in non-clinical research to track changes in tissue-response markers, barrier integrity, and signaling readouts over time (in-vitro and animal models)

Search strings used for each database are presented in Supplementary Table S2

For type 2 diabetes management, the medication may be needed long-term as diabetes is a chronic condition requiring ongoing treatment, though some patients may be able to reduce or discontinue medication if significant weight loss and lifestyle modifications lead to remission of their diabetes

Two practical consequences fall out of this mechanism, and both explain the shape of the protocol below