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Therefore, a tri-agonist was designed, incorporating residues from GLP-1, glucagon and GIP, as well as having a stabilising CEX

In contrast, impaired tissue glucose uptake in response to insulin (a phenomenon called insulin resistance) plays a key role in the development of type 2 diabetes (55)

Contraindications will likely include a history of medullary thyroid cancer or MEN 2 syndrome, and pregnancy

Richards NT, Wood SM, Christofides ND, Bhuttacharji SC, Bloom SR

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