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A 2024 review published in Diabetes, Obesity & Metabolism (cited by Endocrine News, September 2025) put the range at 15% to 60% of total weight lost potentially coming from lean mass - with the spread reflecting real differences in patient age, which drug, and what the person is doing (or not doing) with their nutrition and training

GLP-1 receptor agonists have proven efficacy in weight management and glycemic control, making them a preferred choice among healthcare providers

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In some instances, these injuries require surgery to be repaired and may impact a persons quality of life