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Abstract Glucagon-like peptide 1 (GLP-1)-based therapies, such as semaglutide and tirzepatide, represent highly effective treatment options for people with type 2 diabetes and obesity, enabling effective control of glucose and weight loss, while reducing cardiovascular and renal morbidity and mortality
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Currently, pegvisomant is the only clinically used GHR inhibitor
It is also studied for fatigue, exercise performance, heart health, and male fertility, but benefits outside specific medical indications are less consistent
Clinical pharmacology biopharmaceutics review: Ozempic
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