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The Penn Medicine research suggesting that reward-center effects may be temporary

Limit high-fat and greasy foods, ultra-processed items, carbonated beverages, and alcohol, as these can worsen gastrointestinal side effects like nausea, bloating, and diarrhea

However, it's essential to consult with a healthcare provider to ensure compatibility and avoid potential interactions with other medications or therapies

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By bypassing the harsh acidic environment of the gastrointestinal tract and avoiding first-pass hepatic metabolism, mucosal delivery preserves the structural integrity of the peptides

( f ) protein expression in lysates from 3D AKP organoids treated 5FU for 72 h, representative of n = 3 biological replicates