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Studies on protein therapeutics consistently show that agitation-induced degradation is one of the primary causes of potency loss

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[10] [11] Intramuscular B12 injections (hydroxocobalamin or cyanocobalamin) bypass the digestive system, but UK product information (SmPCs) for hydroxocobalamin injections does list gastrointestinal disturbances, including diarrhoea, as possible adverse reactions, albeit rare

bacteria that can survive in the absence of certain nutrients are used as a readout for mutagenicity