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Metabolomics studies focusing on starvation in echinoderms remain limited, but studies on the crown-of-thorn starfish have documented starvation-induced changes at the gene expression level, linked to glycolysis and the citrate cycle 49 and at the microbiome level, suggesting adaptions in microbial networks during starvation 50 , supporting similar responses of the current investigation, albeit at different levels of biological organization

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We also examined whether expression of Dnmt contributes to global and gene-specific methylations, which alter the expression of vitamin D metabolism genes

These directly damage hepatocyte membranes and mitochondria while depleting GSH, impairing detoxification capacity

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The new GLP1 is produced by drug maker Eli Lilly, designed to be taken once a day to treat obesity and adults