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Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans

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Based on our data, we propose that T3 has a regulatory role in insulin-controlled glucose metabolism, and T3 exerts this function by increasing non-12-OH FXR-antagonistic BA levels via downregulating the expression of CYP8B1, which potentiates GLP-1 production via suppressing the intestinal FXR signaling

10.4067/S0718-95162015005000019 68 HernndezI.ChacnO.RodriguezR.PortielesR.LpezY.PujolM.et al