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9.7.4 Clinical outcomes: glycated hemoglobin (HbA1c) and fasting glucose Meta-analyses of RCTs published between 2023 and 2024 have solidified the clinical relevance of these mechanisms (444)

But theres individual variation

Rare risks include acute pancreatitis and gallbladder disease (Seo YG, J Obes Metab Syndr 2021;30(1):1219)

However, the elimination of publication bias using trim and fill analysis revealed that NAC also could decrease E2 levels and endometrial thickness

The thiamine-induced increases in contractions of the intestine smooth muscle and peristalsis, observed in a number of independent in vitro experiments on muscle strips of gastrointestinal tract (207, 219222), support the action of thiamine on ACh signaling in ENS in the absence of central regulation (236)

A clinical trial has shown that ranirestat affects motor nerve function in mild to moderate DPN