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Course Duration: 10 days Repeat Course: 2 times/year

SREBP1c expression is enhanced in patients with NAFLD, and in agreement with its lipogenic role, hepatic triglyceride levels are higher in transgenic mice overexpressing SREBP1c [44, 45], while SREBP1c knockout mice display decreased expression of lipogenic enzymes [46]

However, elderly patients are at higher baseline risk of long-term PPI-related adverse effects, including: Periodic reassessment of the need for continued PPI therapy is particularly important in elderly patients