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Emerging evidence indicates that growth hormone-releasing peptide Ghrelin and the neurotrophic factor Neuritin suppress neuronal ferroptosis and lipid peroxidation, thereby mitigating brain injury and improving cognitive function
PMID: 40021625 Proc Natl Acad Sci U S A 2021 Jan 12;118(2):e2009539118
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The two peptides come from different structural classes and are studied for activity at different points in the repair cascade.nnBPC-157 is a synthetic 15-amino-acid peptide derived from a partial sequence of a protein found in human gastric juice.nnTB-500 is a synthetic peptide based on the Thymosin Beta-4 sequence, a 43-amino-acid polypeptide naturally expressed in many human tissues.nnThe combination is one of the most-cited multi-peptide reference systems in preclinical regenerative-research literature, used by researchers examining how angiogenic and cytoskeletal-remodelling pathways interact in soft-tissue and musculoskeletal models
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