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Despite evidence of systemic iron and ROS accumulation in FRDA, whether neuronal loss is directly mediated by ferroptosis remains an open question requiring further mechanistic exploration

Figure 1 The selection of aerobic glycolysis and oxidative phosphorylation as energy sources is a marked manifestation of the heterogeneity of ovarian cancer (27)

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Moreover, recent studies are indicating that biological pathways that are melanin-related and the metabolism of vitamin D, which are also affected by complexion, can play a role in the disease, especially for darker-complexioned women (95)