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This is not unheard of, as drugs like pioglitazone and acipimox both reduce metabolic complications without treating obesity at all

[13] Chloramphenicol has been shown to blunt reticulocyte response to cyanocobalamin, while ethanol, colchicine, and nitrous oxide interfere with cobalamin metabolism or utilization, each warranting clinician awareness when evaluating suboptimal treatment outcomes

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If your goal is pure fat loss without muscle growth, AOD-9604 is a great option

IV vitamin B12 therapy is great for quick treatment in serious cases

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