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Clinical trial participants should report any adverse effects promptly to their study team

[3] [4] The appetite suppression is the primary mechanism behind its effectiveness for weight loss

there is about a 2035% risk for congenital defects in infants exposed to the drug in utero , and about 3060% of children exposed to isotretinoin prenatally have been reported to show neurocognitive impairment

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Those with elevated baseline fasting glucose, elevated triglycerides, or metabolic syndrome markers typically show better response to dual-pathway intervention