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Research Highlights Metabolic Regulation and Anti-Obesity Effects: Potent inhibition of nicotinamide N-methyltransferase (NNMT) increases cellular NAD and S-adenosylmethionine (SAM) levels, enhances polyamine flux, boosts energy expenditure, and suppresses lipogenesis
& Surette, M
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NNMT expression is elevated in adipose tissue in obesity, and NNMT activity is associated with lower adipocyte energy expenditure
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