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According to this model, the massive oxidative stress of the initial infection not only depletes glutathione but also partially blocks the body's methylation cycle and folate metabolism

A.ReichheldJ

[1] Glucose-6-phosphate dehydrogenase is an enzyme that protects red blood cells, which carry oxygen from the lungs to tissues throughout the body, from reactive oxygen species

Cahana, I

Alpers disease mutations in human DNA polymerase gamma cause catalytic defects in mitochondrial DNA replication by distinct mechanisms

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