doi:10.2174/1381612826666200523180301 National Center for Biotechnology Information
For biosynthesis, it seems the only strategy to prolong the half-life is a ligand fused with a terminal albumin or Fc domain, whose critical points are length and location
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Solomon SD, Skali H, Anavekar NS, Bourgoun M, Barvik S, Ghali JK, et al