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10.1016/S1474-4422(19)30356-4 27 DeiddaG.BiazzoM
UBQLN2/ubiquilin 2 mutation and pathology in familial amyotrophic lateral sclerosis
The classic presentation includes swelling in one leg (not both, asymmetry is a key indicator), pain or tenderness that often starts in the calf and feels like cramping or soreness, redness or discoloration of the skin over the affected area, and warmth in the swollen area
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