The synthesis of GCL, along with other targets involved in the antioxidant response, is under the control of the transcription factor, Nrf2 (Baird and Dinkova-Kostova 2011)
Accordingly, payers and clinicians will need to implement risk-stratified algorithms, based on non-invasive fibrosis scores, metabolic comorbidities, and patient preferences, to decide who should be treated now, who can safely defer pharmacotherapy, and how limited resources can be deployed most equitably
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