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Limitations of the current study included the single ethnicity design, lack of histopathological and molecular assessment tools of GLP-1RAs-mediated cellular changes and lack of sequential invasive tools in assessment of altered gallbladder motility

"As an obesity medicine physician scientist who regularly cares for patients with complex inflammatory conditions, this study reinforces what many of us have suspected clinically -- that the benefits of GLP-1 receptor agonists extend well beyond blood sugar control and weight loss and may fundamentally alter the disease trajectory for some of our highest-risk patients," Fatima Cody Stanford, M.D., M.P.H., member of the American Heart Association Lifestyle and Cardiometabolic Council, said in a statement

Why Muscle Matters One key concern raised by the findings is that GLP-1 medications can reduce not only fat but also lean muscle mass

It is FDA-approved under two brand names: Wegovy for chronic weight management and Ozempic for type 2 diabetes

Trends in Immunology, 34 , 137143