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Ileal instillation of carbohydrate or lipid induced a more rapid stimulation of GLP-1 (63)
Adding cagrilintide, which has its own GI effects, to an aggressively-dosed retatrutide protocol without careful titration is a recipe for poor tolerance and treatment discontinuation
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The deeper I dug into the science, the clearer the picture became: menopause is a metabolic tipping point, and hormone decline is not neutral
Each step up delivered roughly 3 additional percentage points of weight loss: 1mg produced 8.7%, 4mg hit 15.2%, 8mg reached 21.1%, and 12mg topped out at 24.2%
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