Accordingly, postbiotics should be interpreted as adjunctive nutritional strategies rather than pharmacological alternatives to GLP-1 receptor agonists, with the most plausible utility during consolidation and maintenance phases aimed at improving metabolic context and supporting long-term weight-loss sustainability ( Figure 1 Importantly, accumulating preclinical evidence indicates that certain postbiotic preparations can attenuate weight gain, reduce adiposity, and activate thermogenic pathways, including brown adipose tissue signaling, particularly in high-fat dietfed rodent models
However, there is no FDA-approved indication for this use
Side effects and treatment experience can vary by individual
doi: 10.1017/neu.2019.5 8 BeaulieuJ
Therefore, only trained researchers should handle it under proper rules
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