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Because of this, prescribing information advises informing patients of the potential risk of acute kidney injury due to dehydration and advising them to take precautions to avoid fluid depletion

The new doses (1.5 mg, 4 mg, 9 mg) replace the original doses (3 mg, 7 mg, 14 mg) and provide equivalent clinical effects

The anemia may not be self-limiting in severe cases and the development of acute renal failure from ischemia or haemoglobin casts is a rare complication

For more persistent pigmentation concerns, medical treatments may be required after evaluation by a doctor

doi: 10.1146/annurev.arplant.49.1.249 51 NoctorG.GomezL.VanackerH.FoyerC

This mechanism leads to a reduction in calorie intake and, consequently, weight loss over time