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Cost-effectiveness also merits consideration
The model is then combined with a comprehensive glutathione metabolism model, facilitating the simulation of quinone redox cycling, and adduct-induced GSH depletion
Ganguly P, Alam SF
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However, the possibility of using a non-radioactive cell division marker, BrdU, has provided a new momentum to the field
A 2021 review published in Clinical Pharmacology & Therapeutics noted that most therapeutic peptides undergo proteolytic degradation rather than CYP450-mediated metabolism, making formal hepatic impairment studies less common in peptide drug development [4]
