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(D) Diverse payload classes, encompassing microtubule inhibitors (e.g., auristatins, maytansinoids), DNA-damaging agents (e.g., calicheamicin, duocarmycins, PBDs), topoisomerase I inhibitors (e.g., DXd, SN-38), and other emerging payloads (e.g., RNA polymerase II inhibitors such as amanitins)