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Bibcode:1964Natur.203.1068H
A 2021 paper in Cephalalgia (Schievink et al.) described the same mechanism in spontaneous CSF leaks, where low CSF volume makes patients headache-free lying down but symptomatic upright
So again, everyones story could be different
The development of peptide synthesis changed the field dramatically because it allowed scientists to build peptides in the lab with greater precision
While slower than at 37 C, metabolism at 4 C favors the intracellular acidification, in turn inhibiting pH-sensitive enzymes at rate-limiting steps of glycolysis, the Rapoport-Luebering shunt, and the pentose phosphate pathway (PPP) 11,12
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