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In response to GLP-1 or Ex4, the GLP-1R signals through G-protein-regulated pathways as well as through G-protein-independent pathways by engaging the scaffold protein -arrestin
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214,215,216,217 Additionally, sensory neurons in the dorsal root ganglia (DRG) exhibit altered phenotypes, such as reduced neurofilament synthesis, endoplasmic reticulum stress, and changes in key plasticity molecules, such as growth-associated protein 43 (GAP43) and heat shock proteins, leading to mitochondrial dysfunction and loss of peripheral nerve function
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In this way, rising strong is incredibly powerful
