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34 (2): 2011 Farilla L, Bulotta A, Hirshberg B, et

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Toyota worked out most of the details of lean production and its production system by the early 1960s, and most of its Japanese competitors adopted them as well

The changed electrophoretic isoenzyme pattern may be a sign of a shift in the rate of protein production brought on by ROS-induced DNA damage, which would affect the fractional activities of the proteins [61]

Challenges include metabolic heterogeneity across patient populations, off-target effects of systemic metabolic modulators, and a lack of reliable biomarkers to monitor metabolic changes in vivo