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DMF induces the expression of L-2-hydroxyglutarate dehydrogenase (L2HGDH) to downregulate L-2-hydroxyglutarate (L2HG) and increase global and locus-specific DNA hydroxymethylation levels
The incidence of gastrointestinal adverse events was comparable between the GLP-1RA group (4/131) and the control group (2/131), suggesting that the gastrointestinal tolerability of GLP-1RAs was acceptable in this patient population and did not result in treatment discontinuation
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The same dose of normal saline was used on control mice and IMQ-induced psoriatic mice
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