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The dose starts low and is increased gradually under supervision to reduce digestive side effects while your body adjusts

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Neurology, 54, 230-232

The authors themselves admit this vaguely, saying The majority of participants were female, which might have introduced sex-specific biases in the reported data. Overall the study was 85.5% white, 8.6 Black, 4.5 Asian, 1.2% other, 0.2% missing, and 4.5% Hispanic