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More serious but rare adverse effects can include pancreatitis, gallbladder problems (particularly with rapid weight loss), thyroid-related issues, and in people with type 2 diabetes using semaglutide, potential worsening of diabetic retinopathy

Combined with topiramate, the duo may also increase energy expenditure (the number of calories your body burns)

This substantial difference stems from their fundamentally different mechanisms-Zepbound is a dual GIP and GLP-1 receptor agonist, while Trulicity operates solely as a GLP-1 receptor agonist

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