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Current chemical biology , 8 (2), 89-102

Key Takeaways Microdosing could theoretically reduce peak-to-trough ratios by 28-38%, potentially minimizing side effects Successful precedents exist with insulin and growth hormone therapies using similar principles Mathematical models suggest maintained efficacy (~75-100%) with appropriate dose adjustments Tirzepatide is FDA-approved for weekly dosing only

An ideal linker prevents premature drug release while enabling efficient delivery within the tumor microenvironment

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The most common side effects reported in clinical trials include gastrointestinal symptoms such as nausea, diarrhea, and vomiting