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Fatigue: The bodys adjustment to lower food intake and metabolic changes can cause temporary tiredness
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Genetic variations in GIP and GLP-1 receptor sensitivity, differences in gut microbiome composition, metabolic adaptation, and individual hormonal profiles all influence how much weight a person loses
doi: 10.13005/bpj/2514 77
In the Phase 2 study, participants on retatrutide were still losing weight right up to week 48, suggesting the combination of mechanisms was continuing to work in concert without quickly hitting a biological ceiling
In addition, LDL-cholesterol levels were lower and HDL-cholesterol levels were higher at the end of the trial, indicating improved lipid metabolism (Alvarado, Schoenlau 2016)
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