5.3 Direct neuroprotective and pro-survival pathways In addition to its anti-inflammatory and metabolic effects, semaglutide activates pathways that directly enhance neuronal survival and resilience
GLP-1 acts as a key metabolic regulator, coordinating multiple physiological processes to maintain glucose homeostasis
Current prescribing information lists nausea, vomiting, diarrhea, constipation, and abdominal pain among the more common reactions
Common Dysesthesia Descriptions People with dysesthesia describe sensations as: Burning: Skin feels hot or on fire Like acid under the skin Scalding sensation without heat source Electric/Shock-Like: Lightning bolts shooting through skin Electric zaps or jolts Sharp, quick sensations Tingling/Prickling: Persistent pins and needles Crawling sensation under skin Like insects walking on skin Pressure/Tightness: Constricting band around limb Squeezing sensation Feeling of swelling that isn't there Wetness/Coldness: Skin feels wet but is dry Ice-cold patches Clammy sensation Uncomfortable Touch: Normal touch feels wrong Clothing feels irritating Light touch feels painful (allodynia) Retatrutide-Induced Dysesthesia: What the Trials Show Incidence by Dose (TRIUMPH-4) Key Finding: Dysesthesia is dose-dependent
They were individuals with obesity or overweight, many with type 2 diabetes
AARP Hearing Center Health Benefits of GLP-1s Beyond Weight Loss Popular medications like Ozempic and Wegovy can do more than just help shed pounds The famed quartet of diabetes and weight-loss drugs Ozempic, Wegovy, Zepbound and Mounjaro are well-known for their ability to help people shed pounds, in some cases up to 20 percent of body weight