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a type of hormone that spurs the release of insulin from the pancreascould help treat type 2 diabetes
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Parasympathetic efferent nerves can transmit neuropeptides and acetylcholine to the islet liver, increasing insulin release and liver NO production through muscarinic receptors and lowering blood sugar
Key Findings: Most common: Nausea (43%), diarrhea (33%), vomiting (21%) Unique to retatrutide: Dysesthesia (20.9% @ 12mg in TRIUMPH-4, 8.8% @ 9mg) Discontinuation rate: 18.2% in TRIUMPH-4, 11.3% in TRIUMPH-1 (general obesity population) compared to semaglutide 6.9%, tirzepatide 6.2% Good news: Most side effects peak during dose escalation and improve significantly after week 16 Management: Slow titration, dietary modifications, and proper timing dramatically reduce severity Understanding the Three Categories of Side Effects 1
Novo Nordisk and Eli Lilly, whose GLP-1 diabetes drug Mounjaro is expected to be approved for weight loss this year, are facing several lawsuits in the U.S
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