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Inhibiting mTOR signaling in CAR T cells alters immunometabolism and enhances function Intrigued by our pre- and post-infusion results suggesting a significant role for mTOR activity on the efficacy of CAR T cells of LTR, we asked whether we could harness the mTOR pathway to enhance antitumor activity of CAR T cells of STR

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Caloric restriction (CR) induces the browning of WAT, promotes the development of functional beige fat, and enhances both the type 2 immune response and the expression of silent information regulator type 1 (SIRT1) [31]