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Neither medication is appropriate for patients with type 2 multiple endocrine neoplasia, pregnant individuals, or those with severe renal impairment without dose adjustment
However, users should always verify the source and purity of their products, as the quality control in the gray market remains a significant point of concern for researchers and health enthusiasts alike
NEJM 2022 FDA Approves New Drug Treatment for Chronic Weight Management (Wegovy) FDA Approves New Medication for Chronic Weight Management (Zepbound) Frias JP et al
Time-to-event analyses further indicated delayed time to conception and live birth among semaglutide users, potentially reflecting follicular, endometrial, or endocrine perturbations
Like any medical product, it should be used with proper medical guidance
doi: 10.1038/s41746-025-01992-6 25 BielD.Surez-CalvetM.DewenterA.StewardA.RoemerS
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