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DYRK inhibitors, such as AZ Dyrk1B 33 and ID-8, increase the GLP-1 protein levels in GLUTag cells and the number of L and K cells in zebrafish and diabetic rats
GLP-1 primarily reduces appetite and slows gastric emptying, GIP enhances fat metabolism and insulin sensitivity, and glucagon increases energy expenditure and fat oxidation
*** SHOW NOTES [ 00:00 ] Introduction [ 01:59 ] Truth #1: Standard Doses Are Often Too High [ 02:32 ] Truth #2: Healing Must Come First [ 03:02 ] Truth #3: A Healthier Metabolism Needs Less Medication [ 03:32 ] Truth #4: Side Effects Are Signals, Not the Cost of Entry [ 04:06 ] Truth #5: Reduced Inflammation Is the Real Win [ 04:36 ] Truth #6: Muscle Is Non-Negotiable [ 05:08 ] Truth #7: Slower Weight Loss Is Better Weight Loss [ 05:36 ] Truth #8: Most People Are Using GLP-1s Incorrectly [ 06:05 ] Truth #9: Freedom Is the Goal *** Mentioned in This Episode: Learn how to activate GLP-1 naturally and silence cravings
Nat Rev Mol Cell Biol (2012) 13(4):25162
The effects of magnesium physiological supplementation on hyperactivity in children with attention deficit hyperactivity disorder (ADHD)
J Am Acad Dermatol 49(1):9698
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