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Additionally, obesity and IR both contribute to -cell dysfunction and apoptosis, mechanistically explained by glucotoxicity and increased immunogenicity (the accelerator hypothesis) or by -cell exhaustion due to increased metabolic demand (the overload hypothesis) [23]

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Summary: Weight loss injections can be taken with levothyroxine, but require medical supervision, stable thyroid function, and regular monitoring for potential dose adjustments

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AM: Data curation, Writing original draft, Writing review & editing