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While the nephroprotective effects of SGLT2i were initially derived from secondary endpoints of CV outcome trials (CVOTs), direct confirmation came from dedicated kidney focused trials: CREDENCE (Perkovic et al NEJM 2019| NephJC Summary), DAPA-CKD (Heerspink et al NEJM 2020| NephJC Summary) and finally EMPAKIDNEY (Herrington et al NEJM 2023| NephJC Summary)
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l-Citrulline protects from kidney damage in type 1 diabetic mice
Short checklist before you buy - Does the label name the specific chemical form and dose per serving
A person weighing 180 pounds follows the same 0.25 to 2.4 mg escalation as a person weighing 300 pounds
