doi:10.1038/s41436-021-01173-2
Animal Model:NMRI-Hannover (male, 30 g, deep partial skin thickness burns induced by 5 s direct flame exposure covering 20% total body area) [2] Dosage:i.p.: 10 ng/kg, 10 g/kg
Aging: As individuals age, the tissues supporting the veins can weaken
This includes if symptoms get better and B12 levels in the blood rise
These may include: Nausea Vomiting Diarrhea Constipation Bloating Mild fatigue Symptoms are most common when starting therapy or increasing the dose
As shown in the connected scatterplot in Figure 5 (top), the Sucrosomial B12 formulation rapidly raised circulatory vitamin B12 levels above the deficiency threshold, exceeding 300 pg/mL (borderline level) from day 1, and demonstrated a similar pattern of increasing circulatory vitamin B12 levels over time as observed in the KEMU and LRH studies cohorts, reaching a peak value of 592.7 74.3 at day 7, with all measurements throughout the week being significantly higher than baseline ( p 0.012)