While GLP-1 agonists mimic just one hormone, tirzepatides, such as Zepbound and Mounjaro, mimic twoGLP-1 and gastric inhibitory polypeptide (GIP)which can help overcome plateaus
Side effects what to expect The most common side effects are gastrointestinal and worst in the first 48 weeks (full breakdown in our side-effects guide): Nausea (around 40% of patients in week one usually settles) Constipation or diarrhoea Reflux / burping / "sulphur burps" Reduced appetite (the desired effect) Tiredness and dizziness especially if dehydrated Less common but more serious risks include pancreatitis, gallbladder disease, severe dehydration leading to acute kidney injury, and very rarely thyroid C-cell tumours (seen in rodents human relevance unclear, but the medicines are contraindicated in MEN2 and personal/family history of medullary thyroid cancer)
But that country is making a holistic assessment of the value these drugs can provide and setting costs and access accordingly
They promised cheap access to compounded versions of the medications Ozempic (which includes the active ingredient semaglutide) and Mounjaro in the middle of an unprecedented global shortages
Grand challenges in pharmaceutical research series: ridding the cold chain for biologics
The average retail price for a box of four 5 mg/0.5 mL prefilled pens is around $1,470