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While in a FIGHT trial, liraglutide reduced HbA1c levels (-0.48

Liraglutide and Semaglutide are both GLP1R single-target agonists developed by Novo Nordisk

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The GLP-1 receptor pathway Glucagon-like peptide-1 is secreted by L-cells in the distal small intestine and colon in response to food intake

A similar effect has not been seen in men (Habib et al, 2010) ~50% increased bone fracture risk in women Fluid retention that presents as mild anemia, peripheral edema & associated weight gain Weight gain : all TZDs cause weight gain

So I'm certainly concerned about daily activity, frailty, falling, fractures, and so forth