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Thus, NRF2 target genes appear to play a critical role in mediating the autophagy-dependent effects that regulate stem cell survival

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However, although the data obtained from preclinical studies involving a relatively small number of healthy subjects are promising, further comparative trials in larger populations of people with T2DM and obesity are required to confirm the therapeutic potential of this new GLP-1, GIP, and GCG receptor tri-agonist, particularly in comparison with existing selective GLP-1 and dual GLP-1/GIP receptor agonists

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