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More severe side effects are rare but can include an allergic reaction or the development of blood clots
Blocking NNMT increases intracellular NAD+ and SAM levels key cofactors in energy metabolism
Copper itself is a comparatively weak skin sensitizer a 2014 review (PMID 25098945) reported positive copper patch-test reactions in roughly 3.8% of tested subjects so contact allergy is possible but uncommon
And now its emerging as a powerful tool in longevity science and functional medicine, thanks to its ability to indirectly boost NAD+ levels by slowing the rate of depletion
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