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Underlying health conditions, such as hypothyroidism or PCOS, may slow your progress and are worth discussing with a licensed healthcare provider

Studies have shown that people have regained weight within a year of discontinuing semaglutide injections

However, it takes 4-8 weeks for the drug to reach a steady level in your body

Building on these research findings, Eli Lilly developed a dual agonist targeting GLP-1R/GIPR, called tirzepatide, which was approved by the FDA in 2022 and showed promising therapeutic effects for T2D and obesity

We also assess the potential mechanisms that contribute to the reduction in major adverse cardiovascular events in individuals treated with GLP1R agonists and highlight the emerging cardiovascular biology of novel GLP1-based multi-agonists currently in development

Glucose metabolism and cardiac hypertrophy