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Example of toxic acetylated metabolite Liver damage Highly reactive specie Mechanism of acetylation Acetyl CoA is the activated carrier for acetyl group The reaction catalyzed by the soluble acetyltransferase enzyme: Mainly found in liver Might found in lung, spleen, GIT and red blood cells Acetylation The rate of acetylation is mainly affected by the existence of genetic polymorphism

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USA 103 , 1378913794 (2006)

Mice with this condition were supplemented with UroA, which led to decreased fasting blood glucose, glycated haemoglobin levels, plasma C-peptide, malondialdehyde (MDA) and interleukin-1 levels

The results, which were published in the journal Diabetes Care , found that supplementation restored GSH levels and lowered oxidative damage caused by high glucose numbers