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Because delayed gastric emptying can worsen reflux, the association with GERD has been suspected but not well quantified until now

Severe Gastrointestinal Disease (e.g., Gastroparesis) Mounjaro may worsen symptoms or delay gastric emptying further in patients with preexisting motility disorders

So, its important to watch hydration, electrolytes, blood pressure, and kidney function, especially in the first months of treatment and after increasing the dose

Going from 2 mg directly to 8 mg, or from 4 mg to 12 mg, dramatically increases the risk of severe gastrointestinal events and potential complications

Tail vein samples were obtained for immediate glucose measurement as above, or into lithium heparin-coated microvette tubes for plasma insulin measurement using a mouse insulin-specific HTRF (Cisbio)

Kidney Problems: In rare cases, kidney problems have been reported