what is microdosing a glp 1 should you know before starting GLP-1? Microdosing GLP-1s: How (and Why)

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It has been shown that GLP-1Rs are expressed in POMC neurons in the arcuate, while not in the neuropeptide Y (NPY)/AgRP neurons of the ARC [57,81]

The two reasons are that CBS is activated by estradiol and betaine (Bet), which is twice as high in females compared to males because the enzyme PEMT [Figure 1] is activated by a factor of 2.3 in menstruating females

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